PNH | Ask Alia

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About paroxysmal nocturnal haemoglobinuria (PNH)

What causes PNH?

Paroxysmal nocturnal haemoglobinuria (PNH) is a rare blood disorder that happens when part of your immune system attacks and destroys its own red blood cells (RBCs) in a process called haemolysis. RBCs contain a protein called haemoglobin that carries oxygen around your body.1 As RBCs are broken down, the level of haemoglobin goes down, causing symptoms including anaemia.2–5

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References

  1. Mayo Clinic. Anemia. Available at: https://www.mayoclinic.org/diseases-conditions/anemia/symptoms-causes/syc-20351360. [Accessed October 2024].
  2. PNH Support. What is PNH? Available at: https://pnhuk.org/what-is-pnh/. [Accessed October 2024].
  3. Risitano AM, et al. EHA 2023, 8–11 June; Frankfurt, Germany. Oral S182.
  4. Dingli D, et al. Ann Hematol 2022;101(2):251–263.
  5. Brodsky RA. Blood 2014;124:2804–2811.
 
AUS | AU-27923 | March 2025